ICAM1 rs5498(PMID:12808331)

SNP information:
Gene ID:3383
Genotype:G/A
Functional Consequence:missense,upstream variant 2KB
Global MAF:G=0.3588/1797
DNA change:c.1405A>G
Description:intercellular adhesion molecule 1
Chromosome:19:10285007
Article information:
Method:PCR-RFLP
Population:Korean Case:Control = 197:248
Related disease:Behcet's disease (BD) Year:2003
Allele/Genotype Case Freq.Case Control Freq.Control OR(95%CI) P value Pc value
GG 67 0.34 118 0.476
GA 100 0.508 107 0.431
AA 30 0.152 23 0.093
G 234 343
A 160 0.41 153 0.31 1.25 0.003
Allele/Genotype with skin lesion (N=186) Freq.Case Control Freq.Control OR P value Pc value
GG 61 0.328 118 0.476
GA 96 0.516 107 0.431
AA 29 0.156 23 0.093
G 343
A 0.41 153 0.31 1.29 0.002
Allele/Genotype without skin lesion (N=11) Freq.Case Control Freq.Control OR P value Pc value
GG 6 0.545 118 0.476
GA 4 0.364 107 0.431
AA 1 0.162 23 0.093
G 343
A 0.32 153 0.31 NS
Allele/Genotype with genital ulcers (N=167) Freq.Case Control Freq.Control OR P value Pc value
GG 56 0.335 118 0.476
GA 84 0.503 107 0.431
AA 27 0.162 23 0.093
G 343
A 0.41 153 0.31 1.26 0.004
Allele/Genotype without genital ulcers (N=30) Freq.Case Control Freq.Control OR P value Pc value
GG 11 0.367 118 0.476
GA 16 0.533 107 0.431
AA 3 0.1 23 0.093
G 343
A 0.35 153 0.31 1.89 0.002
Allele/Genotype with ocular lesions (N=151) Freq.Case Control Freq.Control OR P value Pc value
GG 50 0.351 118 0.476
GA 78 0.516 107 0.431
AA 23 0.152 23 0.093
G 343
A 0.41 153 0.31 1.3 0.001
Allele/Genotype without ocular lesions (N=46) Freq.Case Control Freq.Control OR P value Pc value
GG 17 0.348 118 0.476
GA 22 0.5 107 0.431
AA 7 0.152 23 0.093
G 343
A 0.4 153 0.31 NS
Allele/Genotype with vasculitis (N=44) Freq.Case Control Freq.Control OR P value Pc value
GG 14 0.318 118 0.476
GA 22 0.5 107 0.431
AA 8 0.182 23 0.093
G 343
A 0.43 153 0.31 1.1 0.053
Allele/Genotype without vasculitis (N=153) Freq.Case Control Freq.Control OR P value Pc value
GG 53 0.346 118 0.476
GA 76 0.51 107 0.431
AA 22 0.144 23 0.093
G 343
A 0.4 153 0.31 1.22 0.011
Allele/Genotype with arthritis （N=114） Freq.Case Control Freq.Control OR P value Pc value
GG 38 0.333 118 0.76
GA 63 0.553 107 0.431
AA 13 0.114 23 0.093
G 343
A 0.39 153 0.31 1.20 0.11
Allele/Genotype without arthritis （N=83） Freq.Case Control Freq.Control OR P value Pc value
GG 29 0.349 118 0.73
GA 37 0.446 107 0.431
AA 17 0.205 23 0.093
G 343
A 0.43 153 0.31 1.14 0.045
Allele/Genotype with central nervous system （N=11） Freq.Case Control Freq.Control OR P value Pc value
GG 6 0.545 118 0.73
GA 4 0.364 107 0.431
AA 1 0.091 23 0.093
G 343
A 0.27 153 0.31 NS
Allele/Genotype without central nervous system （N=186） Freq.Case Control Freq.Control OR P value Pc value
GG 61 0.328 118 0.73
GA 96 0.516 107 0.431
AA 29 0.156 23 0.093
G 343
A 0.41 153 0.31 1.29 0.002
Allele/Genotype with gastrointestinal （N=11） Freq.Case Control Freq.Control OR P value Pc value
GG 2 0.182 118 0.73
GA 7 0.636 107 0.431
AA 2 0.182 23 0.093
G 343
A 0.5 153 0.31 NS
Allele/Genotype without gastrointestinal （N=186） Freq.Case Control Freq.Control OR P value Pc value
GG 65 0.349 118 0.73
GA 93 0.505 107 0.431
AA 28 0.151 23 0.093
G 343
A 0.4 153 0.31 1.25 0.008
Function:Undone
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Wang Q, Su G, Tan X, et al. UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases. Hum Mutat, 2019, 40: 258-266. Pubmed
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